Are You Using this Controversial Baldness Treatment

No one should have to choose between their hairline and their health. But increasingly, men who use finasteride, commonly known as Propecia, to treat their male pattern baldness are making that choice, often unwittingly. In the 17 years since Propecia was approved to treat hair loss from male pattern baldness, so many disturbing urogenital and other side effects have emerged, the term Post Finasteride Syndrome (PFS) has been coined and hundreds of lawsuits have been brought.

Finasteride inhibits a steroid responsible for converting testosterone into 5-dihydrotestosterone (DHT) the hormone that tells hair follicles on the scalp to stop producing hair. Years before Propecia was approved to grow hair, finasteride was used in drugs like Proscar, Avodart and Jalyn to treat an enlarged prostate gland (benign prostatic hyperplasia). Like Viagra, which began as a blood pressure med, or the eyelash growing drug Latisse, which began as a glaucoma drug, finasteride's hair restoration abilities were a fortuitous side effect.

Since Propecia was approved for sale in 1997, its label has warned about sexual side effects. "A small number of men experienced certain sexual side effects, such as less desire for sex, difficulty in achieving an erection, or a decrease in the amount of semen," it read. "Each of these side effects occurred in less than 2% of men and went away in men who stopped taking PROPECIA because of them." (The label also warned about gynecomastia, the enlargement of male breast tissue.)

But increasingly, users and some doctors are saying the symptoms sometimes do not "go away" when men stopped taking Propecia and that their lives can be changed permanently. They report impotence, lack of sexual desire, depression and suicidal thoughts and even a reduction in the size of penises or testicles after using the drug which do not go away after discontinuation.

According to Dr. Andrew Rynne, former head of the Irish Family Planning Association and well-known surgeon, Merck, who makes Propecia and Proscar, knows that the disturbing symptoms do not always go away. "They know it is not true because I and hundreds of other doctors and thousands of patients have told them that these side effects do not always go away when you stop taking Propecia. We continue to be ignored of course."

In some cases, says Dr. Rynne, men who have used the finasteride for even a few months "have unwittingly condemned themselves to a lifetime of Sexual Anhedonia," a [condition in which an individual cannot feel pleasure from orgasm], the most horrible and cruel of all sexual dysfunctions."

"I have spoken to several young men in my clinic in Kildare who continue to suffer from sexual anaesthesia and for whom all sexual pleasure and feelings have been obliterated for all time. I have felt their suffering and shared their devastation," he says on a Propecia help site.

Sarah Temori, who launched a petition to have finasteride taken off the market on Change.org, agrees. "Many who have taken Propecia have lost their marriages, jobs and some have committed suicide due to the damage this drug has done to their bodies," she writes. "One of my loved ones is a victim of this drug. It's painful to see how much he has to struggle just to make it through each day and do all the daily things that we take for granted. No doctors have been able to help him and he is struggling to pay for medical bills. He is only 23." Stories about Propecia's disturbing and underreported side effects have run on CNN, ABC, CBS, NBC, Fox and on Italian and English TV news.

The medical literature has also investigated finasteride effects. A study last year in the Journal of Sexual Medicine noted "changes related to the urogenital system in terms of semen quality and decreased ejaculate volume, reduction in penis size, penile curvature or reduced sensation, fewer spontaneous erections, decreased testicular size, testicular pain, and prostatitis." Many subjects also noted a "disconnection between the mental and physical aspects of sexual function," and changes to mental abilities, sleeping patterns, and/or depressive symptoms.

A study this year in the Journal of Steroid Biochemistry and Molecular Biology finds that "altered levels of neuroactive steroids, associated with depression symptoms, are present in androgenic alopecia patients even after discontinuation of the finasteride treatment."

Approved in Haste, Regretted in Leisure

The rise and fall of Propecia parallels other drugs like Vioxx or hormone replacement therapy that were marketed to wide demographics even as safety questions nipped at their heels. Because two thirds of American men have some hair loss by age 35, and by age 50, 85 percent of men do, Propecia had the promise of a blockbuster like Lipitor or Viagra.

Early ads likened men's thinning scalps to crop circles. Later, ads likened saving scalp hair to saving the whales and won awards. Many Propecia ads tried to take away the stigma of hair loss and its treatment. "You'd be surprised who's treated their HAIR LOSS" said one print ad depicting athletic looking, twenty-something men. In 1999 alone, Merck spent $100 million marketing Propecia directly to consumers, when direct-to-consumer advertising was just beginning on TV.

Nor was Propecia only sold in the U.S. Oversees ads compared twins who did and did not use the product. Propecia sponsored New Zealand's World Rally Championship in 2005. In the U.K., the drug store chain Boots aggressively marketed Propecia at its 300 stores and still does. One estimate says Propecia was marketed in 120 countries--half the world.

In 2003, it gained a warning for patients to promptly report any "changes in their breasts, such as lumps, pain or nipple discharge, to their physician." Soon, "male breast cancer" was added under "Postmarketing Experience." In 2010 depression was added as a side effect and patients were warned that finasteride could have an effect on prostate-specific antigen (PSA) tests. In 2011, the label conceded that sexual dysfunction could continue "after stopping the medication" and that finasteride could pose a "risk of high-grade prostate cancer." In 2012, a warning was added that "other urological conditions" should be considered before taking finasteride. In 2013, the side effect of angioedema was added.

Propecia Users Speak Out

There are many Propecia horror stories on sites founded to help people with side effects and those involved in litigation. In 2011, a mother told CBS news she blamed her 22-year-old son's suicide on Propecia and Men's Journal ran a report called "The (Not So Hard) Truth About Hair Loss Drugs."

In a database of more than 13,000 finasteride adverse effects reported to the FDA, there were 619 reports of depression and 580 reports of anxiety. Sixty-eight users of finasteride reported a "penis disorder" and small numbers reported "penis deviation," "penis fracture" and "micropenis." On the patient drug review site Askapatient.com, the 435 reviews of Propecia cite many examples of depression, sexual dysfunction and shrunken penises.

One of the most visible faces for Post Finasteride Syndrome is 36-year-old UK resident Paul Innes. Previously healthy and a soccer player, Innes was so debilitated by his use of Propecia, prescribed by his doctor, he has founded a web site and gone public. Appearing on This Morning earlier this year, Innes describes how using Propecia for only three months on one occasion and three weeks on another produced a suicidal depression requiring hospitalization, sexual dysfunction and a reduction on the size of his reproductive anatomy--none of which went away when he ceased the drug. He and his former girlfriend seated next to him, Hayley Waudby, describe how the physical and emotional changes cost them their relationship itself, even though she is pregnant with his child. The TV segment was ironically sponsored by Boots, the UK drug chain which aggressively advertises its Propecia-based hair loss clinics and through which Innes ordered his Propecia the second time. "With very little effort my pills arrived to my home address in the post," he writes.

In an email I asked Paul if his health were improving after the ordeal. This is what he wrote back. "My health is just the same if not worse since 2013. I am still impotent with a shrunken penis and still have very dark thoughts and currently having to take anti depressants just to get through everyday. Prior to Propecia I was a very healthy guy but now I'm a shadow of my former self. I have only just managed to return to work in my role as a police officer since taking Propecia in March 2013! On his web site he adds PROPECIA IS LETHAL - DO NOT EVEN CONSIDER TAKING IT !!!

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