VALENCIA, Spain and BRUSSELS, July 03, 2024 (GLOBE NEWSWIRE) -- Seeking alternatives to obtain oocytes without ovarian
stimulation is a pioneering line of research in reproductive medicine. The inconveniences that the process of ovarian
stimulation can generate are a current barrier for some women and couples who are considering starting a reproductive
treatment. In fact, 1 out of every 5 couples do not start the search for a second child for this reason.
Ovarian stimulation is the initial part of assisted reproduction treatments, and it is the phase of infertility
treatments in which the least relevant advances have been achieved to date. It is one of the main psychological barriers
for women when deciding to begin this path towards motherhood. Many of them are concerned about how this process may
affect them physically and emotionally.
With the aim of making progress in this field, IVI RMA GLOBAL has signed an exclusive agreement with Lavima Fertility,
Inc., a US company in the fertility sector which owns the rights to CAPA-IVM, a completely novel hormone-free fertility
treatment technology. Together, IVI RMA Global and Lavima Fertility have opened a pioneering line of research aimed at
eliminating ovarian stimulation in women who wish to begin assisted reproduction or egg vitrification treatment.
"We are aware that the ovarian stimulation phase can be faced with some anxiety and can be a brake on the decision to
begin treatment. For this reason, at IVI and together with Lavima Fertility, we have taken the initiative and we are
going to challenge science to try to optimize this very delicate part of the treatment for some patients," explains Dr.
Nuria Pellicer, gynecologist at IVI Valencia.
A clinical study has begun at the IVI Valencia headquarters under the direction of Dr. Ernesto Bosch, director of the
clinic, and Dr. Nuria Pellicer, together with the scientific director of IVI RMA Global, Dr. Juan Antonio García
Velasco. Lavima Fertility is supporting this clinical study by providing the CAPA-IVM and culture media supplements that
allow immature oocytes to mature outside of the women’s ovaries in vitro and without the need of ovarian stimulation.
This investigation will later be joined by the rest of the IVI RMA Global group's clinics.
"Our main objective is to continue benefiting women through research, and to eliminate the psychological barrier of
those who decide not to start treatment, worried about the physical and emotional effect that ovarian stimulation may
have on them, although the symptoms associated with this process are usually moderate and pass in a few days," says Dr.
Bosch.
In spite of being a fundamental step in the treatment of fertility, it is estimated that 20% of couples who would like
to look for a second child do not do so due to their reluctance regarding the possible effects of ovarian stimulation:
"Finding formulas to improve this process from science is an exciting and hopeful project for us, in our continuous
research work, and allows us to continue helping in a pioneering way and with the latest advances to women who trust us
with their greatest desire," concludes Dr. Pellicer.
"Avoiding controlled ovarian stimulation together with the trigger hormones in ART represents clearly a great scientific
and clinical innovation," says Prof. Dr. Johan Smitz from Lavima Fertility.
Immature eggs are retrieved from unstimulated small follicles. The oocyte-cumulus-complexes are then matured in a novel
two-step process in vitro using several culture media supplements. This technology is called CAPA-IVM. Five randomized
clinical studies have been conducted in Asia and over 850 babies have been born already using this novel hormone free
fertility treatment technology, underlying the safety of CAPA-IVM.
"We are excited about the research collaboration between IVI RMA Global and Lavima Fertility in the field of
hormone-free fertility treatment. IVI RMA Global is the largest IVF chain in the world and working together with IVI RMA
Global clinics in this field would allow to bring CAPA-IVM to many more patients worldwide in the future," concludes
Prof. Smitz