Breast Cancer Trails Herald Hope
New results from one of the world’s largest breast cancer trails herald hope for thousands of women
Benefits of Arimidex (anastrozole) over tamoxifen at preventing all forms of breast cancer recurrence increase over time - even four years after treatment ends
San Antonio, USA, Friday 14 December 2007: New data from ATAC*, one of the world’s largest and longest-running studies in postmenopausal women with early breast cancer, reinforce that anastrozole can help many more women live cancer-free, for longer. For the first time, follow-up research shows anastrozole to be better than tamoxifen in preventing tumours from returning long term.1,2 If cancer returns, women are much more likely to die – therefore, preventing breast cancer from returning (“recurrence”) at any stage of treatment is key to saving lives.
The landmark results – presented today at the prestigious annual San Antonio Breast Cancer Symposium (SABCS), USA and also published online in The Lancet Oncology –show that even four years after a woman’s treatment ends, the protective effect of anastrozole in reducing the risk of hormone-sensitive early breast cancer from returning continues to increase. Overall, women in the ATAC trial taking anastrozole were 24% less likely to have their cancer come back, compared with those taking tamoxifen.1,2 This demonstrates the long-term impact of treatment decisions made at diagnosis and confirms the importance of starting treatment with anastrozole to help more women beat this devastating disease. Breast cancer currently affects 1.1 million women worldwide per year 3 and hormone-sensitive early disease accounts for around 75% of all cases of breast cancer in postmenopausal women. 4
Presenting the data at SABCS, Professor John Forbes, Newcastle Mater Misericordiae Hospital, Australia commented: “Preventing recurrence is the primary goal in breast cancer management. If we can stop the cancer from returning, we can save more lives, more often. These exciting long-term follow-up data show that anastrozole is a more effective treatment option than tamoxifen for postmenopausal women with hormone-sensitive early stage disease – thus it is imperative these women get the most effective treatment at the earliest opportunity after diagnosis.”
Professor Forbes continued: “Prior to the ATAC trial, tamoxifen was the standard of care for women with hormone-sensitive disease, with substantial evidence to support its crucial place in practice. However, these new 100-month data from ATAC show us that compared with tamoxifen, anastrozole can significantly reduce the risk of recurrence and minimise life-threatening side effects. Most encouragingly, the data also show us that the protective effect of anastrozole lasts well beyond the standard treatment period of five years and in my opinion confirms there is no longer any rationale for prescribing tamoxifen.”
A recent global survey showed that over 70% of physicians believe that telling a patient her breast cancer has come back is worse than giving a diagnosis of early breast cancer.6 Recurrence, in the same breast, in the opposite breast or at a distant tumour site means that the cancer is more likely to be incurable and the patient is at risk of a bad outcome. It is therefore essential for both patients and their doctors to know they are on a better therapy than tamoxifen to prevent the disease returning.
The impact of treatment on quality of life is also an important consideration in early breast cancer, and data have shown that the clinical benefits of anastrozole are achieved without adversely affecting the quality of patients’ lives.5
“The ATAC 100-month
data confirm that anastrozole is now the gold standard
treatment for post-menopausal women with hormone-sensitive
early breast cancer, irrespective of their recurrence risk,
and is set to improve the outcomes of patients
worldwide,” commented Professor Anthony Howell,
Christie Hospital, UK.
Notes
Arimidex
(anastrozole) is a trademark, the property of the
AstraZeneca group of companies.
* ATAC: Arimidex,
Tamoxifen, Alone or in Combination Trial studied
postmenopausal women diagnosed with early breast cancer in
the poast five years and who had undergone breast cancer
surgery.
ATAC 100-month results summary:
The study will be published early online (00.01GMT Saturday 15 December) and in the January edition of The Lancet Oncology
‘More Positive
Conversations’ global survey
The ‘More Positive
Conversations’ survey was conducted online and via
telephone interviews by Harris Interactive on behalf of
AstraZeneca. The survey involved 1,062 physicians and
patients from France, Germany, Italy, the United Kingdom and
the US.
AstraZeneca
AstraZeneca is a major
international healthcare business engaged in the research,
development, manufacture and marketing of prescription
pharmaceuticals and the supply of healthcare services. It is
one of the world's leading pharmaceutical companies with
healthcare sales of $26.47 billion and leading positions in
sales of gastrointestinal, cardiovascular, neuroscience,
respiratory, oncology and infection products. AstraZeneca is
listed in the Dow Jones Sustainability Index (Global) as
well as the FTSE4 Good Index.
References
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