Tuesday 26 September 2017
Lactation hormone also helps a mother’s brain: Otago research
The same hormone that stimulates milk production for lactation, also acts in the brain to help establish the nurturing
link between mother and baby, University of Otago researchers have revealed for the first time.
The researchers found that signalling by the hormone prolactin to its receptors in a specific brain region is essential
for mothers to show vitally important maternal nurturing behaviour towards their young. This finding raises the
question, is this brain circuitry the “feel good” factor to encourage breast feeding?
Prolactin is best known for its role in enabling milk production in mammals.
The research team at the University’s Centre for Neuroendocrinology undertook targeted deletion of prolactin receptors
in the preoptic area of the brains of adult female mice.
Study co-author Dr Rosie Brown says the team observed that these mice without prolactin receptors were able to get
pregnant and give birth normally, but abandoned their litters around 24 hours after birth.
The research is newly published in the prestigious international journal PNAS.
“Our findings establish a critical role for prolactin for more than simply milk production. This work is the first to
show this hormone is a literal life saver in that it establishes and maintains the normal parental care that ensures
offspring survival.”
Disruptions in the ability of prolactin to communicate in the brain could lead to problems for mothers establishing a
bond with their baby. This may in part explain issues with some animal species abandoning their young, she says.
This work was supported by Health Research Council of New Zealand Grant and a Marsden Grant from the Royal Society of
New Zealand.
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